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276 Pathological prion instigates neuronal death, which in turn causes secondary astrocytic reactivity predominantly in the white matter, but the roles of reactive astroglia in prion diseases are poorly understood and hampered by the emerging complexity of astrocyte responses to prion induced pathologies

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Importantly, this inflammation is not inherently harmfulrather, it is necessary for triggering tissue repair, immune regulation, and remodeling [26, 27]

Annu Rev Med (2015) 66:34359

However, most negative side effects occur due to excessive consumption of both