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For the study, researchers evaluated the dermatologic and injection-site reaction safety of GLP-1RAs via a meta-analysis of randomised controlled trials (RCTs) and a disproportionality analysis of data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS)

Total reduction in spot ultraviolet, spot polarization, and skin tone were measured and recorded using a Janus Facial Analysis System (PIE Co., Ltd, Suwon-si, Gyeonggi-do, Korea)

At study start, male C57BL6J WT, as well as global Glp-1r / and Gipr / deficient mice were continued to be housed at thermoneutrality (28 C) and given ad libitum access to a HFD (60% fat, D12492