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Dose escalation schedules amplify these effects early in therapy and then permit physiological adaptation, which is why many patients see gradual improvement

Delayed Response of Amylin Levels after an Oral Glucose Challenge in Children with Prader-Willi Syndrome

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IGF-1 elevation occurs within 4 weeks, but fat loss and lean mass preservation don't appear until weeks 812 due to the lag between hormonal signaling and tissue-level enzyme upregulation