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Therefore, we chemically synthesized the relevant macrocycles with C-terminal (-alanine) 2 -FLAG tags (A 2 -FLAG), with the resulting peptides referred to as aML5-FLAG, aMD4-FLAG and aMD5-FLAG (Supplementary Table 2 and Supplementary Fig

They bind to complementary sequences on target mRNAs, resulting in negative regulation through degraded target mRNA or repressed the translation (Beermann et al., 2016)

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2017;56(11):948957.e4

2 hours before completion of acetylcysteine infusion check ALT/AST and paracetamol concentration to determine need for ongoing acetylcysteine