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Figure 3 Activated IRE1 regulates gene expression by increasing ER protein folding capacity via TRAF2

A pivotal study demonstrated that culturing laryngeal cancer cells under hypoxic conditions upregulated Notch1 expression and activity, which in turn increased the expression of the MDR1 and survivin genes, conferring resistance to chemotherapy [47]

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GLP-1 medications may reduce these thoughts for some patients, but they can return after treatment ends

The approach to management of physical activity and nutrition in the setting of AID has changed considerably [116] since these guidelines have been published