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Lesjak M, Simin N, Srai SKS

Unconjugated NAPQI which overwhelms the capability of endogenous GSH to reduce it can bind to cellular proteins damaging them in the process and inducing cell death [15]

Oo AM, Nor MNM, Lwin OM, Simbak N, Adnan LHM, Rao USM

These include: Nausea, vomiting, and diarrhoea (very common, especially during dose escalation) Reduced appetite and abdominal discomfort Constipation Risk of hypoglycaemia when used with insulin or sulphonylureas Pancreatitis and gallbladder disease have been reported Thyroid C-cell tumours have been observed in animal studies, though the relevance to humans is unknown Important safety considerations when using both treatments include: Mounjaro can reduce the effectiveness of oral contraceptives due to delayed gastric emptying