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The trade-off is randomization: participants may be assigned to placebo or a lower dose arm, and the protocol imposes constraints on concurrent medications and lifestyle modifications that may not reflect individual patient circumstances
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Among 21,822 people of European ancestry, we required participants to have complete data needed to construct the target phenotype and GWAS covariates (that is, data available for pre-treatment weight, post-treatment weight, drug type, dosage, time on treatment and factors such as age, sex and height), resulting in 18,488 participants
Related: Can You Ask If Someone's Taking a GLP-1
