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To date, the underlying factor(s) responsible for the thyroid changes remains obscure and is probably multifactorial

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Phase 2b randomized trial of the oral PCSK9 inhibitor MK-0616

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In the Phase 2 Jastreboff trial, patients escalated through six dose levels over approximately 24 weeks before reaching one of three maintenance doses (4 mg, 8 mg, or 12 mg weekly)

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