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Figure 2 5.1 A new perspective on the pathogenesis of diabetes: beyond insulin deficiency While diabetes has traditionally been characterized by insulin deficiency or resistance, accumulating evidence suggests that hyperglucagonemia and impaired glucagon signaling are equally critical contributors to its pathogenesis

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The following potential mechanism is proposed: l-carnitine prolongs the ability of endothelial cells to regulate blood flow during ischaemia, and an increase in serum carnitine concentration enhances capillary endothelial function [38]

Mycobiome and Inflammatory Bowel Disease: Role in Disease Pathogenesis, Current Approaches and Novel Nutritional-based Therapies