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Pre-existing osteoarthritis, increased physical activity, dehydration, and weight-loss-triggered gout flares may also contribute
For those with established atherosclerosis, the focus would be on managing the existing condition and preventing further progression [31]
Heterogeneity The significant heterogeneity in most of our efficacy outcomes could not be resolved by a leave-one-out test or sensitivity analysis due to the inclusion of only two studies in our efficacy analysis
Contraindications include personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, and severe gastroparesis
FIGURE 3 8.4 Health economics and access: important implementation questions, but no PCOS-ART-specific economic evidence yet A structural tension exists between the clinical promise and the cost of GLP-1RAs
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