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Simultaneously, some cells undergo cell cycle arrest and become senescent owing to the inhibition of cyclin-dependent kinases mediated by p21 activation through the DDR pathway 11

Active liver disease impairs copper clearance and increases the risk of copper accumulation

[DOI] [PubMed] [Google Scholar] 288.Brcic L., Brcic I., Staresinic M., Novinscak T., Sikiric P., Seiwerth S

Wound healing tolerates daily injection seven days a week because the treatment window is short

Beyond directly damaging mitochondrial components, ROS oxidize LDL to form ox-LDL, which promotes atherosclerosis by driving macrophage-to-foam cell formation [131, 132]