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Collectively, the selenoprotein translation machinery consists of SECIS element, SBP2, Sec-specific eukaryotic elongation factor (EEFSEC), and aminoacylated Sec-tRNA [Ser]Sec , thereby enabling UGA to be recognized as a Sec codon and utilized for translation into the growing polypeptide

Using cell death kinetic analysis, gene-editing and metabolic tracing, we show that inhibition of RNR-dependent nucleotide metabolism allows for conservation of intracellular GSH and a reduction in ferroptosis susceptibility in cancer cells

(April 2003)