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It is contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

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Since Shh -expressing placode cells generate the majority of cells in hair peg, including those still expressing Shh , this intriguing change in cell fate indicates that progenies of Shh -expressing placode cells separate into two different populations: the population still expressing Shh loose the potential to form HFSCs, while the cells with down regulated Shh expression in hair peg can presumably still become HFSCs

In clinical trials, hair loss was reported in 4-5% of people using tirzepatide (Zepbound) compared to 1% on placebo