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Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y et al
This tri-receptor activity profile is what separates it from earlier compounds like semaglutide (GLP-1 only) and tirzepatide (GLP-1/GIP), and is the basis for the significant fat loss results observed in Phase 2 clinical trials
A bispecific antibody targeting IGF-IR and EGFR has tumor and metastasis suppressive activity in an orthotopic xenograft osteosarcoma mouse model
Unlike SGLT2 inhibitors, tirzepatide does not increase glucose in urine and clinical trials found no elevated UTI risk compared to placebo