[38] In consequence, Japanese individuals homozygous or, to only a slightly lesser extent, heterozygous for glu487lys metabolize ethanol to acetaldehyde normally but metabolize acetaldehyde poorly and are susceptible to a set of adverse responses to the ingestion of, and sometimes even the fumes from, ethanol and ethanol-containing beverages
GPx4 uses the reducing power of glutathione to convert highly toxic lipid hydroperoxides into harmless, non-toxic lipid alcohols
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Of note, such metabolomic alterations can be observed in the R group 12 months after the acute disease