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Furthermore, the GCGR may play a role in renal energy metabolism, and GLP-1R/GCGR dual agonists such as 1907B have shown superior efficacy to GLP-1R single agonists in murine DN models, more effectively reducing proteinuria and improving renal function [232]

Acknowledgements We would like to thank all the Congolese participants of this study for kindly donating specimens for proteomics analysis

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in Innovative Medicine 3949 (Springer, 2015)

Adverse events (AEs) were recognized as negative or unpredictable medical manifestations throughout the whole study