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(12) observed that the presence of a polymorphism of the CYP1A1 gene (metabolising enzyme that intervenes in the activation of various carcinogens), consisting of the Ile genotype in homozygosity, led to susceptibility to develop LC in smokers with centriacinar emphysema (OR =2.45

Overall our data indicate that glutathione metabolism is differently affected in the two resistant strains and that glutathione system may play an important role in the global organization of C.albicans cells for resistance to fluconazole

Leitinger, B

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