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At first, the surface of the cartilage becomes worn, and with the continuation of the pathological process, deep cracks related to the shedding of cartilage fragments gradually forms, causing delamination and exposure of the calcified cartilage and bone below (Burr and Schaffler, 1997

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The SLC7A11-containing cystine/glutamate antiporter system xc supports cysteine availability after imported cystine is reduced, although its contribution depends on nutrient conditions and transporter expression (Jyotsana et al., 2022)