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"Our study shows that patients treated for obesity with semaglutide or tirzepatide lost less weight on average in a regular clinical setting compared to what is observed in randomized clinical trials." Hamlet Gasoyan, PhD, Researcher, Cleveland Clinics Center for Value-Based Care Research Maintaining weight loss presents different challenges for each approach

Possible causes include dehydration, inadequate calorie or carbohydrate intake, low blood pressure, constipation, poor sleep, anemia, nutrient insufficiency, blood sugar changes, or medication intolerance