adverse side effects of glp 1 GI Glucagon-Like Peptide-1 Receptor Agonists ⚠️ New Sensory Side Effects

Regulatory Toxicology and Pharmacology Journal 2006;46(1):23-28

In the palmitic acid (PA)-induced ceramide synthase 6 (CERS6)-deficient HK-2 and CERS6 knockdown db/db mouse models, aggravation of DKD symptoms and renal interstitial fibrosis were found, possibly due to the interaction of CERS6-derived ceramide with PINK1 to inhibit PINK1/Parkin-mediated mitophagy, which aggravates DKD [118]

IGF-1 naturally declines with age, and it is drastically reduced by oral estrogen in the oral birth control pill and by oral forms of estrogen used for menopausal HRT (transdermal estrogen does not have the first pass through the liver so does not decrease IGF-1)

Reducing oxidative stress lowers glutathione turnover, allowing levels to rise [20]

Unlike the business center, English proficiency among locals in the old quarters of Kowloon City may be lower