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A biotin deficiency results in brittle nails, hair loss, dry skin

Metformin was first introduced in France in 1957 but wasnt approved to treat type 2 diabetes in the US until 1994 under the brand name Glucophage

A very high dose of 30 g shows little difference between males and females

If you already have a diagnosed deficiency under NHS care and your symptoms return before your next scheduled dose, that is a conversation to have with your GP, who can review the schedule