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A trial factor was investigated for the single-dose scintigraphy trial, owing to a slight under-estimation of concentrations in this trial by the model, but the trial factor was not statistically significant and was not included (OFV = 5.749)
Further development of TGR-based therapeutic approaches is impeded by the lack of non-covalent small molecule inhibitors of TGR, a well-known and general problem for all the members of the high molecular weight, Sec-containing TrxR subfamily that are considered attractive and unexploited drug targets for several human diseases 21,22
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