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Additionally, GLP1RAs significantly reduce the expression of MMP9, VEGF, and ICAM1 and inhibit the ERK1/2 and AKT/PKB signalling pathways, thereby alleviating inflammatory responses and vascular leakage, further protecting the BRB [52, 67]

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In a combination protocol, some researchers theorize that starting at a lower dose (1mg daily) and assessing tolerance before escalating to the full 2mg might reduce the risk of compounding side effects with retatrutide

Slower digestion and absorption of nutrients: This allows your body to feel satiated for longer, reducing calorie intake