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Sustained Effect : The long-acting nature of semaglutide provides sustained blood glucose control and supports long-term medical weight loss

The prevalence of this condition has nearly tripled in the time span between 1975 and 2016

At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems

doi: 10.1016/j.neuropharm.2013.08.005 45 KimSMoonMParkS

Clinical trials proving their effectiveness also included education on nutrition and physical activity, which are essential for achieving meaningful results