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[1] [3] The medication primarily targets metabolic and appetite-regulating pathways rather than the hormonal pathways typically associated with hot flushes, such as oestrogen or testosterone regulation, or the neurotransmitter systems involved in thermoregulation

Altered scapular movement patterns are present in virtually all chronic shoulder conditions and must be corrected for lasting improvement

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Therefore, avoiding these medications may be recommended as a precautionary measure for those with a personal or family history of these conditions