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In the supraspinatus, chronic ischemia, mechanical unloading, and inflammation elevate mitochondrial ROS production, while antioxidant defenses-such as SODs, GPXs, and glutathione-are impaired, disrupting redox balance

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Moreover, yohimbine at a dose of 5 mg effectively alleviated oxidative stress by lowering the level of MDA in the liver of obese rats

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Mechanism: GLP-1 receptor activation blunts appetite, slows gastric emptying, and promotes insulin release