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they are not proven in humans

Bone (2002) 30(1):30713.10.1016/S8756-3282(01)00662-7 17 Nuche-BerenguerBMorenoPEsbritPDapiaSCaeiroJRCancelasJet alEffect of GLP-1 treatment on bone turnover in normal, type 2 diabetic, and insulin-resistant states

These structural proteins give skin its firmness and prevent sagging