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A study in 73 healthy adolescents using 24-hour GH sampling found mean integrated GH concentrations of 3.8 ng/mL in mid-puberty compared with 1.1 ng/mL in young adults, a 3.5-fold difference [5]

This increase occurred because semaglutide delays gastric emptying, giving levothyroxine more time in the gastrointestinal tract for absorption