Dosage adjustments may be necessary to optimize results and minimize side effects like nausea or digestive discomfort
The FLOW trial, a double-blind, placebo-controlled study examining renal outcomes in patients with type 2 diabetes and chronic kidney disease, demonstrated that semaglutide reduced the progression of kidney disease by 24% compared to placebo
Additionally, tirzepatide did not attenuate the reduction of sleeping metabolic rate or 24-h sedentary energy expenditure in comparison to baseline (though not significantly different than placebo), but significantly increased fat oxidation and decreased carbohydrate and protein oxidation as compared to placebo [57]
People with insulin resistance manifest impaired insulin action in all insulin target organs/tissues including skeletal muscle, cardiac muscle, liver, adipose tissue, and brain, as well as the vasculature
PMID: 8551864 Bowers, C.Y., et al