Losing the weight addresses each of these at the root, and for some men, tirzepatide can be a clinically supported way to get there
Selenoprotein P is synthesized mostly in the liver (75%), but its plasma levels reflect the functional Se status in the whole organism (57)
People who had their gallbladder removed should keep in touch with their doctor
Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018 Jul;154:161-171. doi: 10.1016/j.bcp.2018.05.003. Epub 2018 May 5. PMID: 29738706; PMCID: PMC6015571
Cutler R, Packer L, Bertram J, Mori A (2012) Oxidative stress and aging, 1st edition, Birkhuser Basel , Switzerland