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Plasma levels of homocysteine and cysteine increased in pediatric NAFLD and strongly correlated with severity of liver damage

Choline and betaine intakes are not associated with cardiovascular disease mortality risk in Japanese men and women

Environmental modifications include maintaining comfortable indoor temperatures (68-72F), using heating pads or warm blankets, and taking warm baths or showers

While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)

These ingredients include all 8 high potency B vitamins to support energy and metabolism*