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No electron density was detected at the helix 14 site of 1907, likely due to its lower affinity compared to the helix 23 site, as calculated by NMR and SPR

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With these introductory considerations in mind, I review findings from many different viruses with a particular focus on HIV and SARS-CoV-2 and consider our current understanding of the mechanisms of antibody-mediated neutralization in vitro, the antiviral mechanisms of nAbs that become relevant if effector cells are included in typical in vitro assays and the mechanisms of nAb activity against viruses in vivo