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However, in acute intensive care unit (ICU) settings, where patients require mechanical respiratory support, a multitude of factors including infection, accumulation of inflammatory cells, airway dehydration, reduced cough reflexes, supra-normal oxygenation, and mechanical stress from ventilation can lead to changes in mucus characteristics and increased mechanical impedance to mucociliary clearance

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Yaribeygi H, Maleki M, Butler AE, et al

69 Increasing research has shown that in addition to the increased incidence of colorectal cancer, UC patients have an increased risk of extraintestinal cancers, 70 such as pancreatic cancer, 71 prostate cancer, 72 hepatocarcinoma, 73 and anal cancer