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GLP-1 class: do not combine Combining semaglutide with other GLP-1 agonists (liraglutide, dulaglutide) or with GLP-1-containing multi-agonists (tirzepatide, retatrutide) risks unpredictable GLP-1 receptor overstimulation, compounded GI toxicity, and uncontrolled metabolic effects

MK, MK-2305

For TMT labelling, peptide concentrations were adjusted to 1 g/L, and TMTpro 16-plex reagents (Thermo Fisher Scientific) dissolved in anhydrous acetonitrile (ACN) were added at a 4:1 TMT:peptide ratio

Effects on the Immune System Opioids have been shown to have a variety of effects on components of the immune system

Potential Risks Typical side effects are local injection-site pain, redness, mild swelling, headaches, and light-headedness