is glp-1 safe to use medications like Ozempic, Wegovy and Mounjaro are changing diabetes and weight management, but they aren't recommended during pregnancy or while nursing. The current recommendation stop before conception and discuss The ABC's of GLP-1s: Benefits,

Dose-by-dose weight loss in Phase 2 (NEJM) Phase 2 NEJM weight loss by dose, 24 and 48 weeks Dose 1 mg 24 weeks -7.2% 48 weeks -8.7% Dose 4 mg 24 weeks -12.9% 48 weeks -17.5% Dose 8 mg 24 weeks -15.7% 48 weeks -22.8% Dose 12 mg 24 weeks -17.5% 48 weeks -24.2% Dose Placebo 24 weeks -1.6% 48 weeks -2.1% Source: Jastreboff et al., NEJM 2023

Running retatrutide after completing a semaglutide or tirzepatide protocol If you have completed a full semaglutide or tirzepatide protocol and are starting retatrutide as a new treatment after a break, the standard dose schedule applies without modification

Daniel Drucker [Biomarker April 2023] 5

occasionally added to patches for metabolism or muscle support appeal

Earliest commercial availability: approximately 2028 to 2030