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Encouragingly, ongoing trials, such as EVOKE and EVOKE+, are already exploring this potential for early Alzheimer's disease

J Clin Endocrinol Metab (2002) 87(3):123946

Costs remain a major barrier, particularly for semaglutide and tirzepatide, while liraglutide has become more affordable since its patent expired

Common during caloric deficit, especially in the first few weeks

These multifaceted metabolic effects position dual GLP-1/GIP receptor agonists as superior therapeutic candidates for MASLD, especially in patients with coexisting obesity and T2DM, where dysregulated glucose and lipid metabolism drive the progression of the disease