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Data availability The cryo-EM density maps of SCF FBXO22 -UNC10088 C -NSD2 PWWP1, SCF FBXO22 - UNC10415667 C -NSD2 PWWP1, and SCF FBXO22 -UNC10088 C -NSD2 PWWP1-BACH1 BTB were deposited in the Electron Microscopy Data Bank under accession numbers EMD-57178, EMD-57180, and EMD-57179, respectively

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