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Available from: Accessed February 03, 2026

In addition to augmenting insulin secretion, it inhibits glucagon release, improving glycemic control

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NNMT upregulation also elevates homocysteine levels, activating pro-inflammatory and pro-oxidative cascades (TLR4-NF-B and STAT3-IL-1 pathways) linked to atherosclerosis, heart failure, and coronary heart disease

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