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PINK1 targets dysfunctional mitochondria for autophagy in Parkinson disease

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Although GSH pathway genes play an important role in the detoxification of NAPQI, individually they did not appear to be useful biomarkers for variation in NAPQI-dependent cytotoxicity

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this, in turn, resulted in the upregulated expression of telomere repeat-binding factor 1/2 (TRF1/TRF2) proteins and strict dependence on p53/p21 signaling, followed by irreversible G2/M cell cycle arrest, ultimately leading to apoptosis

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