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In 1972, Svetlana Mojsov was a PhD student at Rockefeller University in New York City under the tutelage of biochemist Bruce Merrifield, who had developed a new, efficient way to produce peptides in a lab (for which he would win a Nobel Prize in 1984) called solid-phase peptide synthesis. For her doctoral thesis, Mojsov used this method to achieve something that had eluded researchers for decades: She successfully synthesized glucagon, a complex hormone the body produces to raise blood sugar levels when necessary, which was of particular interest to endocrinologists as a potential treatment for diabetes

Copper peptides do not act on G-protein coupled receptors like GLP-1 agonists, so downregulation is theoretically less likely

At these two concentrations of exenatide, the mean HR increased by up to 16.8 bpm compared with an increase of 5.5 bpm with placebo

Both may be helpful for the right patient and inappropriate for another

The gut houses about 80% of the immune system