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32 (Figures 1b,c and 2b,c)

Ishizawa J, Zhao R, Heese L, Jaeger A, Nishida Y, Jacamo RO, Kojima K, John Ma MC, Ruvolo V, Chachad D, Devine W, Lindquist S, Davis R, Porco JA, Jr, Whitesell L, Andreeff AM

In the paraventricular nucleus (PVN), GLP-1 enhances AMPA receptor-mediated excitatory postsynaptic currents, which increases corticotropin-releasing hormone (CRH) neuron activity and promoting anorexigenic signaling [[17], [18], [19]]

Bioscience Reports, May 2021, ePublication 3

Specifically, drug abuse, drug withdrawal syndrome, and prescription drug used without a prescription were reported more than 3.5 times as frequently, and intentional product use issue was reported almost two times as frequently indicating that further studies are essential to determine the extent and type of semaglutide misuse/abuse among the general public and vulnerable sub-groups of individuals