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It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation

To test whether GH signaling in AgRP neurons regulates energy homeostasis in other conditions of nutrient deficiency, control and AgRP GHR KO male mice received i.p

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Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, et al