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Boschetto P, Miotto D, Bononi I, Faggian D, Plebani M, Papi A, Creminon C, De Rosa E, Fabbri LM, Mapp CE

Mechanistically, xCT controls the transfer of cysteine and the maintenance of intracellular redox dynamics, and the deletion of xCT in tumor cells leads to defective cystine uptake, accumulation of reactive oxygen species, and impaired tumor growth

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Retatrutide also represents a new class of drugs that could have broad applications, further expanding Eli Lilly's market opportunity