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The actions of norepinephrine and epinephrine are exerted via receptor-mediated signal transduction events

However, this is not the entire explanation, as estradiol also stimulates GPX, resulting in higher GPX flux that removes more mass from GSH

The synergy claim is mechanistic, derived from the three peptides acting on different nodes of overlapping pathways (VEGF, NF-kB, ECM remodeling)

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Glutathione is also essential for brain function, metabolic and biochemical reactions such as DNA synthesis and repair, and is critical in supporting the health of organs such as the lungs and kidneys