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However, potential side effects such as hypoglycemia appear to be limiting factors in the usefulness of IGF-1 for clinical treatment of muscle wasting conditions

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Its cytotoxicity is strictly proportional to mitochondrial respiratory activity, making it exquisitely potent against metabolically hyperactive or drug-refractory sub-clones ( Although systemic induction of cuproptosis shows potential for cancer therapy, off-target toxicity and systemic adverse effects remain unavoidable

doi: 10.1136/gut.51.4.536 8 Perez-ColonEDadlaniGHWilmotIMillerM