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Background An increasing trend of Parkinson's disease (PD), as the neurodegenerative illness, has been reported, and it is more prevalent in countries with high human development and sociodemographic indicators (1)

Most side effects resolve within 2 to 4 weeks

Sirt1 activation protects the mouse renal medulla from oxidative injury

Management outcomes highlight the need for individualized and multidisciplinary approaches to improve symptom control and quality of life

Secondary objectives were change from baseline to week 3 for tirzepatide versus placebo in fasting and postprandial appetite VAS ratings, FCI, FCQ-S, Eating Inventory, PFS questionnaire ratings and BOLD activation to photos of Food HiPal (Food HiF/HiS and Food HiF/HiC ) relative to non-food during the fasting state in the prespecified principal reward ROIs