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STAT3 activation by catalpol promotes osteogenesis-angiogenesis coupling, thus accelerating osteoporotic bone repair

The other is osteoprotegerin (OPG), a member of the tumor necrosis factor receptor (TNFR) superfamily, with a stronger affinity to RANKL than RANK, which can competitively prevent RANKL from binding to RANK, thus inhibiting osteoclast differentiation and bone resorption activity and inducing its apoptosis

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Many clinicians also track outcomes with photos or skin analysis to document before-and-after progress