adults have used glucagon-like peptide-1 (GLP-1) drugs for weight loss or diabetes, a number that has tripled since 2020, with high interest particularly among women aged 50 to 64
doi:10.1074/jbc.M114.588913 Green DR, Galluzzi L, Kroemer G (2014) Cell biology
Glucagon-Like Peptide-1-(7-36)Amide Is Transformed to Glucagon-Like Peptide-1-(9-36)Amide by Dipeptidyl Peptidase IV in the Capillaries Supplying the L Cells of the Porcine Intestine
People taking GLP-1 medications commonly report reduced food cravings, less emotional eating, and a quieting of the constant mental preoccupation with food that researchers call "food noise." Animal studies have also shown that GLP-1 receptor activation reduces the rewarding properties of high-calorie food in the brain findings confirmed in a landmark randomized, placebo-controlled neuroimaging study in humans ( van Bloemendaal et al., Diabetes, 2014 )
Bottom line: High-dose supplements are useless if the body cannot absorb them