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If pharmaceutical companies or researchers wanted to move this idea forward, it would require showing that leptin is adding a benefit on top of GLP-1s, said Jens Holst, a professor of physiology at the University of Copenhagen

Heckl et al., 2021)

[5] These findings inform strict contraindications and mandatory wash-out intervals when nitrates are part of the therapeutic regimen

This is likely explained by studies that show L-citrulline ingestion to be the most efficient means of elevating plasma arginine concentrations, which in turn, produces NO (Schwedhelm et al