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The MHRA/EMC SmPC highlights additional important safety concerns including: Risk of pancreatitis (presenting as severe abdominal pain) Gallbladder disease including cholelithiasis Dehydration potentially leading to acute kidney injury Potential worsening of diabetic retinopathy in patients with pre-existing disease, particularly with rapid glycaemic improvement Nutritional considerations are paramount

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A common reconstitution is 2mL of water for a 5mg vial of BPC 157

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Eli Lilly is also developing oral GLP-1 receptor agonists, including compounds such as orforglipron, which have shown significant weight loss and glycemic improvements in Phase III clinical trials

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